Figure 5

Annotated genes and segment data obtained from different array CGH experiments for prostate tumor tissue shown at the 21q22 locus. The segments below a threshold of -0.55 for the Taylor data (colored gray) and -0.25 for the FISH Oracle data (shown in orange) indicate interstitial deletions covering a 3 Mbp genomic segment. The breakpoints are located within the genes TMPRSS2 and ERG (indicated by red boxes), leading to the characteristic TMPRSS2:ERG fusion bond in about 40-60% of prostate cancers [44]. Segment captions are not shown to make the resulting image more compact.