Figure 5

Molecular interactions in apical transport of the ciliary body epithelia. Molecular network build in Ingenuity (http://www.Ingenuity.com), representing possible transporters in the apical plasma membranes of the pigmented and non-pigmented epithelia that transport the apical extracellular excreted entries outlined in Figure 4. The top functions assigned by Ingenuity to this network were “Neurological disease, psychological disorders and cell-to-cell signaling and interaction”. The major transport mechanisms to which these genes were connected were vesicle-mediated transporters (ANXA7, CAV1, CLTA, CLTC, and SORL1) and lipid (ABCA1, LDLR and SCARB1) and xenobiotic (ABCC5 and ABCG2) transporters. Two PE signature genes, ABCA1 and SLC40A1 (yellow symbols) are involved in this network. Legends of different lines: see Figure 4.