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Table 6 NCI-Nature pathway interactions associated with top 80 genes selected by BMI

From: A filter-based feature selection approach for identifying potential biomarkers for lung cancer

NCI-Nature Pathway Interaction p-value Associated genes
ATF-2 transcription factor network 6.8276E-5 ATF3, FOS, DUSP10
Downstream signaling in naïve CD8+ T cells 1.8173E-4 B2 M, EGR1, FOS
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 2.6255E-4 EGR1, MAP2K4, APC
Ephrin B reverse signaling 8.6116E-4 CXCR4, MAP2K4
ErbB1 downstream signaling 8.7013E-4 MAP2K4, FOS, EGR1
Regulation of p38-alpha and p38-beta 0.0011 DUSP10, MAP2K4
Direct p53 effectors 0.0013 APC, MSH2, ATF3
Trk receptor signaling mediated by the MAPK pathway 0.0014 EGR1, FOS
RhoA signaling pathway 0.0021 FOS, MAP2K4
IL6-mediated signaling events 0.0023 MAP2K4, FOS
Presenilin action in Notch and Wnt signaling 0.0024 FOS, APC
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.0025 EGR1, FOS
Regulation of Androgen receptor activity 0.0027 EGR1, MAP2K4
Fc-epsilon receptor I signaling in mast cells 0.0041 FOS, MAP2K4
IL12-mediated signaling events 0.0045 B2 M, FOS
HIF-1-alpha transcription factor network 0.0052 FOS, CXCR4
CDC42 signaling events 0.0058 APC, MAP2K4
Regulation of nuclear SMAD2/3 signaling 0.0075 FOS, ATF3
Glucocorticoid receptor regulatory network 0.0077 FOS, EGR1
Sumoylation by RanBP2 regulates transcriptional repression 0.0174 RANBP2
JNK signaling in the CD4+ TCR pathway 0.0206 MAP2K4
Ras signaling in the CD4+ TCR pathway 0.0222 FOS
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0284 TCEB2
Cellular roles of Anthrax toxin 0.0346 MAP2K4
VEGFR3 signaling in lymphatic endothelium 0.0361 MAP2K4
S1P2 pathway 0.0377 FOS
PDGFR-alpha signaling pathway 0.0377 FOS
ALK1 signaling events 0.0392 ACVR2A
Signaling events mediated by PRL 0.0392 EGR1
TRAIL signaling pathway 0.0438 MAP2K4
Regulation of CDC42 activity 0.0453 APC
S1P3 pathway 0.0453 CXCR4
CD40/CD40L signaling 0.0469 MAP2K4
Canonical Wnt signaling pathway 0.0469 APC
p38 MAPK signaling pathway 0.0469 TXN
Calcium signaling in the CD4+ TCR pathway 0.0484 FOS
Nongenotropic Androgen signaling 0.0484 FOS
Nephrin/Neph1 signaling in the kidney podocyte 0.0499 MAP2K4
IL12 signaling mediated by STAT4 0.0499 FOS