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Figure 3 | Journal of Clinical Bioinformatics

Figure 3

From: Quantitative analysis of histone exchange for transcriptionally active chromatin

Figure 3

Histone exchange occurs more readily in chromatin containing transcription activating PTMs. (A) The average and standard error of isotopically light arginine containing peptides for bulk H3, H3K9acK14ac, H2B-TAP, and 15 non-specifically associating proteins are plotted as a function of formaldehyde cross-linking. (B) Plot of bulk H4, H4K12acK16ac, H2B-TAP, and 15 non-specific proteins as a function of formaldehyde cross-linking. Levels approaching 100% light peptides indicate minimal histone exchange while levels at ~50% light peptides reflect rapid exchange.

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