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Figure 4 | Journal of Clinical Bioinformatics

Figure 4

From: FISH Oracle: a web server for flexible visualization of DNA copy number data in a genomic context

Figure 4

Annotated genes and segment data obtained from different array CGH experiments for prostate tumor tissue shown at the 10q23 locus. The segments colored in orange correspond to the FISH Oracle data. The gray segments are derived from the Taylor data. Both data sets show an accumulation of segments in the region from 89 Mbp to 91 Mbp. The minimal overlapping region indicated by the FISH Oracle data extends from about 89.6 Mbp to 90.2 Mbp, containing the genes PTEN and C10orf59. The minimal overlapping region indicated by the Taylor data overlaps almost exactly with the gene PTEN. The region around PTEN is shown in a red box. It overlaps with several deletions, as only segments with a mean intensity threshold less than -0.7 for the Taylor data and less than -0.35 for the FISH Oracle data, are shown. PTEN [43] is a known tumor suppressor gene which can lead to tumor development if it is deleted. Especially in prostate tissue, the deletion of a chromosomal region containing PTEN leads to tumor development.

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