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Table 2 Significant changes in protein expression levels as judged with G-test under p< 0.05 for an LCNEC vs. SCLC pair.

From: Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study

No

Entry name

Accession number

Proteins

G

P

Rsc

Spectral counts

       

LCNEC SCLC

1

AK1C3

P42330

Aldo-keto reductase family 1 member C3

39.1

3.93E-10

4.91

25

0

2

AK1C1

Q04828

Aldo-keto reductase family 1 member C1

37.4

9.56E-10

4.86

24

0

3

FABP7

O15540

Fatty acid-binding protein, brain

21.9

2.89E-06

4.22

15

0

4

ENOB

P13929

Beta-enolase

22.2

2.50E-06

3.61

18

1

5

AL1A1

P00352

Retinal dehydrogenase 1

11.8

6.07E-04

3.55

9

0

6

4F2

P08195

4F2 cell-surface antigen heavy chain

11.8

6.07E-04

3.55

9

0

7

1C12

P30508

HLA class I histocompatibility antigen, Cw-12 alpha chain precursor

11.8

6.07E-04

3.55

9

0

8

TBA4A

P68366

Tubulin alpha-4A chain

11.8

6.07E-04

3.55

9

0

9

LG3BP

Q08380

Galectin-3-binding protein precursor

20.6

5.77E-06

3.54

17

1

10

1C03

P04222

HLA class I histocompatibility antigen, Cw-3 alpha chain precursor

10.1

1.48E-03

3.40

8

0

11

TKT

P29401

Transketolase

8.46

3.62E-03

3.24

7

0

12

VTNC

P04004

Vitronectin precursor

6.85

8.87E-03

3.05

6

0

13

G6PD

P11413

Glucose-6-phosphate 1-dehydrogenase

6.85

8.87E-03

3.05

6

0

14

PRDX4

Q13162

Peroxiredoxin-4

6.85

8.87E-03

3.05

6

0

15

VDAC1

P21796

Voltage-dependent anion-selective channel protein 1

6.85

8.87E-03

3.05

6

0

16

1B15

P30464

HLA class I histocompatibility antigen, B-15 alpha chain precursor

6.85

8.87E-03

3.05

6

0

17

VILI

P09327

Villin-1

6.85

8.87E-03

3.05

6

0

18

DESP

P15924

Desmoplakin

11.19

8.24E-04

2.96

11

1

19

AHSA1

O95433

Activator of 90 kDa heat shock protein ATPase homolog 1

5.27

2.18E-02

2.84

5

0

20

COPB

P53618

Coatomer subunit beta

5.27

2.18E-02

2.84

5

0

21

TMEDA

P49755

Transmembrane emp24 domain-containing protein 10 precursor

5.27

2.18E-02

2.84

5

0

22

CD44

P16070

CD44 antigen precursor

5.27

2.18E-02

2.84

5

0

23

COPA

P53621

Coatomer subunit alpha

5.27

2.18E-02

2.84

5

0

24

TBB4Q

Q99867

Putative tubulin beta-4q chain

5.27

2.18E-02

2.84

5

0

25

THIL

P24752

Acetyl-CoA acetyltransferase, mitochondrial precursor

5.27

2.18E-02

2.84

5

0

26

EFTU

P49411

Elongation factor Tu, mitochondrial precursor

14.88

1.14E-04

2.47

19

4

27

IDHP

P48735

Isocitrate dehydrogenase [NADP], mitochondrial precursor

13.55

2.32E-04

2.39

18

4

28

LRC47

Q8N1G4

Leucine-rich repeat-containing protein 47

5.41

2.01E-02

2.39

7

1

29

CO6A1

P12109

Collagen alpha-1(VI) chain precursor

4.08

4.34E-02

2.20

6

1

30

PSA

P55786

Puromycin-sensitive aminopeptidase

4.08

4.34E-02

2.20

6

1

31

IMB1

Q14974

Importin subunit beta-1

5.95

1.47E-02

2.17

9

2

32

PSA2

P25787

Proteasome subunit alpha type-2

4.72

2.99E-02

2.02

8

2

33

FAS

P49327

Fatty acid synthase

9.93

1.63E-03

1.93

18

6

34

A1AT

P01009

Alpha-1-antitrypsin precursor

4.05

4.41E-02

1.62

10

4

35

ROA1

P09651

Heterogeneous nuclear ribonucleoprotein A1

6.43

1.12E-02

1.58

16

7

36

FINC

P02751

Fibronectin precursor

8.01

4.64E-03

1.57

20

9

37

TRAP1

Q12931

Heat shock protein 75 kDa, mitochondrial precursor

6.26

1.24E-02

1.50

17

8

38

MYH14

Q7Z406

Myosin-14

6.26

1.24E-02

1.50

17

8

39

ANXA2

P07355

Annexin A2

5.46

1.94E-02

1.49

15

7

40

PHB2

Q99623

Prohibitin-2

4.67

3.07E-02

1.49

13

6

41

GSTP1

P09211

Glutathione S-transferase P

10.63

1.12E-03

1.38

32

17

42

PDIA1

P07237

Protein disulfide-isomerase precursor

8.96

2.76E-03

1.33

29

16

43

1433G

P61981

14-3-3 protein gamma

8.11

4.40E-03

1.28

28

16

44

ACTN4

O43707

Alpha-actinin-4

8.82

2.98E-03

1.26

31

18

45

PCBP2

Q15366

Poly(rC)-binding protein 2

5.03

2.49E-02

1.16

21

13

46

TPIS

P60174

Triosephosphate isomerase

6.45

1.11E-02

1.12

28

18

47

TRFE

P02787

Serotransferrin precursor

7.17

7.41E-03

1.12

31

20

48

ARF1

P84077

ADP-ribosylation factor 1

5.00

2.53E-02

1.09

23

15

49

PCBP1

Q15365

Poly(rC)-binding protein 1

4.31

3.79E-02

1.01

23

16

50

CO6A3

P12111

Collagen alpha-3(VI) chain precursor

5.16

2.31E-02

0.91

32

24

51

EF1A1

P68104

Elongation factor 1-alpha 1

4.72

2.98E-02

0.83

35

28

52

PDIA6

Q15084

Protein disulfide-isomerase A6 precursor

4.01

4.52E-02

0.81

31

25

53

G3P

P04406

Glyceraldehyde-3-phosphate dehydrogenase

14.21

1.64E-04

0.77

113

95

54

ENPL

P14625

Endoplasmin precursor

5.76

1.64E-02

0.66

62

56

55

TBB2A

Q13885

Tubulin beta-2A chain

5.80

1.61E-02

0.63

69

64

56

VIME

P08670

Vimentin

5.92

1.49E-02

0.60

77

73

57

HBB

P68871

Hemoglobin subunit beta

4.88

2.72E-02

-0.53

53

110

58

TBB5

P07437

Tubulin beta chain

10.89

9.64E-04

-0.63

81

179

59

TBA1A

Q71U36

Tubulin alpha-1A chain

14.38

1.49E-04

-0.67

93

211

60

TBB2B

Q9BVA1

Tubulin beta-2B chain

5.93

1.49E-02

-0.69

35

82

61

H2B1B

P33778

Histone H2B type 1-B

6.45

1.11E-02

-0.83

25

65

62

LMNB1

P20700

Lamin-B1

7.27

7.03E-03

-0.87

25

67

63

HBA

P69905

Hemoglobin subunit alpha

5.77

1.63E-02

-0.92

17

48

64

CALM

P62158

Calmodulin

3.90

4.82E-02

-1.00

9

28

65

HNRH1

P31943

Heterogeneous nuclear ribonucleoprotein H

4.36

3.67E-02

-1.01

10

31

66

NUMA1

Q14980

Nuclear mitotic apparatus protein 1

4.83

2.80E-02

-1.01

11

34

67

LAP2A

P42166

Lamina-associated polypeptide 2 isoform alpha

5.31

2.13E-02

-1.05

11

35

68

H31T

Q16695

Histone H3.1t

6.23

1.26E-02

-1.06

13

41

69

GDIA

P31150

Rab GDP dissociation inhibitor alpha

7.65

5.67E-03

-1.09

15

48

70

TBA1C

Q9BQE3

Tubulin alpha-1C chain

14.23

1.62E-04

-1.12

27

86

71

TBA1B

P68363

Tubulin alpha-1B chain

35.27

2.88E-09

-1.16

63

202

72

K1C19

P08727

Keratin, type I cytoskeletal 19

10.64

1.11E-03

-1.19

17

58

73

HSP76

P17066

Heat shock 70 kDa protein 6

6.46

1.10E-02

-1.23

9

33

74

H12

P16403

Histone H1.2

7.59

5.87E-03

-1.31

9

35

75

TBB4

P04350

Tubulin beta-4 chain

12.66

3.73E-04

-1.50

11

48

76

MOES

P26038

Moesin

4.51

3.36E-02

-1.51

3

16

77

KU70

P12956

ATP-dependent DNA helicase 2 subunit 1

22.32

2.31E-06

-1.64

16

75

78

DYHC1

Q14204

Cytoplasmic dynein 1 heavy chain 1

8.54

3.48E-03

-1.67

5

27

79

RBBP4

Q09028

Histone-binding protein RBBP4

6.58

1.03E-02

-1.74

3

19

80

PGS1

P21810

Biglycan precursor

3.99

4.59E-02

-1.81

1

10

81

ROA1L

Q32P51

Heterogeneous nuclear ribonucleoprotein A1-like protein

7.30

6.89E-03

-1.81

3

20

82

HNRPF

P52597

Heterogeneous nuclear ribonucleoprotein F

4.77

2.90E-02

-1.93

1

11

83

RUXG

P62308

Small nuclear ribonucleoprotein G

6.40

1.14E-02

-2.15

1

13

84

1433S

P31947

14-3-3 protein sigma

4.19

4.08E-02

-2.21

0

7

85

PEG10

Q86TG7

Retrotransposon-derived protein PEG10

4.19

4.08E-02

-2.21

0

7

86

CAYP1

Q13938

Calcyphosin

4.19

4.08E-02

-2.21

0

7

87

GBB1

P62873

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

4.19

4.08E-02

-2.21

0

7

88

NCA11

P13591

Neural cell adhesion molecule 1, 140 kDa isoform precursor

4.19

4.08E-02

-2.21

0

7

89

FSCN1

Q16658

Fascin

5.11

2.38E-02

-2.37

0

8

90

ROA0

Q13151

Heterogeneous nuclear ribonucleoprotein A0

8.98

2.74E-03

-2.43

1

16

91

MDHC

P40925

Malate dehydrogenase, cytoplasmic

7.00

8.13E-03

-2.66

0

10

92

H2A1D

P20671

Histone H2A type 1-D

8.94

2.79E-03

-2.89

0

12

93

SEGN

O76038

Secretagogin

15.915

6.63E-05

-3.51

0

19

94

MAP1B

P46821

Microtubule-associated protein 1B

16.926

3.89E-05

-3.58

0

20

95

BASP

P80723

Brain acid soluble protein 1

24.067

9.30E-07

-3.99

0

27

  1. Proteins are listed in descending order of R sc values, pooled spectral counts are listed, and "_HUMAN" are removed from UniProtKG entry names.