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Table 3 KEGG Pathway analysis

From: Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection

Outdegree/Betweenness Centrality
Cluster KEGG pathway Percentage P-value
3 no pathway   
15 B cell receptor signaling pathway 11.5 8.00E-03
17 RIG-I-like receptor signaling pathway 21.1 6.30E-06
  Cytosolic DNA-sensing pathway 15.8 5.30E-04
  Toll-like receptor signaling pathway 10.5 6.70E-02
18 Natural killer cell mediated cytotoxicity 16.7 2.60E-03
  Graft-versus-host disease 11.1 4.00E-02
  Allograft rejection 11.1 4.00E-02
20 drug metabolism 10.8 1.30E-03
23 Jak-STAT signaling pathway 6.0 9.60E-03
  Lysosome 4.8 2.80E-02
  Cell adhesion molecules (CAMs) 4.8 5.30E-02
24 Cytokine-cytokine receptor interaction 22.7 4.50E-05
  Chemokine signaling pathway 18.2 5.90E-04
  NOD-like receptor signaling pathway 13.6 1.70E-03
  Cytosolic DNA-sensing pathway 9.1 5.60E-02
  Hematopoietic cell lineage 9.1 8.50E-02
  Toll-like receptor signaling pathway 9.1 9.90E-02
29 Proteasome 6.3 1.00E-03
  Apoptosis 4.8 5.40E-02
  Toll-like receptor signaling pathway 4.8 6.80E-02
33 Aldosterone-regulated sodium reabsorption 3.4 7.40E-03
Indegree
Cluster KEGG pathway Percentage P-value
7 DNA replication 9.7 4.60E-09
  Mismatch repair 5.6 9.40E-05
8 Apoptosis 3.2 1.40E-02
  p53 signaling pathway 2.4 6.00E-02
9 Chemokine signaling pathway 8.9 8.80E-03
  Jak-STAT signaling pathway 6.7 5.20E-02
10 Antigen processing and presentation 8.7 2.40E-05
  Allograft rejection 7.2 7.20E-04
  Endocytosis 8.7 1.00E-03
  Viral myocarditis 5.8 5.90E-03
11 Complement and coagulation cascades 8.2 3.10E-05
  Cytokine-cytokine receptor interaction 9.6 1.70E-03
14 Natural killer cell mediated cytotoxicity 13.5 5.00E-08
  T cell receptor signaling pathway 8.5 8.70E-04
  Primary immunodeficiency 5.4 5.70E-03
  Cell adhesion molecules (CAMs) 8.1 2.80E-03
  Leukocyte transendothelial migration 6.8 6.80E-03
  Cytokine-cytokine receptor interaction 8.1 1.90E-02
  Cell adhesion molecules (CAMs) 3.8 1.70E-02
  Cytokine-cytokine receptor interaction 8.1 1.90E-02
  Cell adhesion molecules (CAMs) 3.8 1.70E-02
22 DNA replication 3.4 2.30E-03
  Cytokine-cytokine receptor interaction 5.2 3.80E-02
23 Jak-STAT signaling pathway 6.0 9.60E-03
  Cell adhesion molecules (CAMs) 4.8 5.80E-02
24 Cytokine-cytokine receptor interaction 22.7 5.40E-05
  Chemokine signaling pathway 18.2 5.90E-04
  NOD-like receptor signaling pathway 13.6 1.70E-03
32 Cytokine-cytokine receptor interaction 19.6 2.00E-09
  NOD-like receptor signaling pathway 8.9 5.30E-05
  Toll-like receptor signaling pathway 8.9 1.30E-04
  1. All top scorer clusters, with regard to indegree, outdegree and betweenness centrality metrics, were checked for enriched KEGG pathways.