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Table 3 KEGG Pathway analysis

From: Dynamic gene network reconstruction from gene expression data in mice after influenza A (H1N1) infection

Outdegree/Betweenness Centrality

Cluster

KEGG pathway

Percentage

P-value

3

no pathway

  

15

B cell receptor signaling pathway

11.5

8.00E-03

17

RIG-I-like receptor signaling pathway

21.1

6.30E-06

 

Cytosolic DNA-sensing pathway

15.8

5.30E-04

 

Toll-like receptor signaling pathway

10.5

6.70E-02

18

Natural killer cell mediated cytotoxicity

16.7

2.60E-03

 

Graft-versus-host disease

11.1

4.00E-02

 

Allograft rejection

11.1

4.00E-02

20

drug metabolism

10.8

1.30E-03

23

Jak-STAT signaling pathway

6.0

9.60E-03

 

Lysosome

4.8

2.80E-02

 

Cell adhesion molecules (CAMs)

4.8

5.30E-02

24

Cytokine-cytokine receptor interaction

22.7

4.50E-05

 

Chemokine signaling pathway

18.2

5.90E-04

 

NOD-like receptor signaling pathway

13.6

1.70E-03

 

Cytosolic DNA-sensing pathway

9.1

5.60E-02

 

Hematopoietic cell lineage

9.1

8.50E-02

 

Toll-like receptor signaling pathway

9.1

9.90E-02

29

Proteasome

6.3

1.00E-03

 

Apoptosis

4.8

5.40E-02

 

Toll-like receptor signaling pathway

4.8

6.80E-02

33

Aldosterone-regulated sodium reabsorption

3.4

7.40E-03

Indegree

Cluster

KEGG pathway

Percentage

P-value

7

DNA replication

9.7

4.60E-09

 

Mismatch repair

5.6

9.40E-05

8

Apoptosis

3.2

1.40E-02

 

p53 signaling pathway

2.4

6.00E-02

9

Chemokine signaling pathway

8.9

8.80E-03

 

Jak-STAT signaling pathway

6.7

5.20E-02

10

Antigen processing and presentation

8.7

2.40E-05

 

Allograft rejection

7.2

7.20E-04

 

Endocytosis

8.7

1.00E-03

 

Viral myocarditis

5.8

5.90E-03

11

Complement and coagulation cascades

8.2

3.10E-05

 

Cytokine-cytokine receptor interaction

9.6

1.70E-03

14

Natural killer cell mediated cytotoxicity

13.5

5.00E-08

 

T cell receptor signaling pathway

8.5

8.70E-04

 

Primary immunodeficiency

5.4

5.70E-03

 

Cell adhesion molecules (CAMs)

8.1

2.80E-03

 

Leukocyte transendothelial migration

6.8

6.80E-03

 

Cytokine-cytokine receptor interaction

8.1

1.90E-02

 

Cell adhesion molecules (CAMs)

3.8

1.70E-02

 

Cytokine-cytokine receptor interaction

8.1

1.90E-02

 

Cell adhesion molecules (CAMs)

3.8

1.70E-02

22

DNA replication

3.4

2.30E-03

 

Cytokine-cytokine receptor interaction

5.2

3.80E-02

23

Jak-STAT signaling pathway

6.0

9.60E-03

 

Cell adhesion molecules (CAMs)

4.8

5.80E-02

24

Cytokine-cytokine receptor interaction

22.7

5.40E-05

 

Chemokine signaling pathway

18.2

5.90E-04

 

NOD-like receptor signaling pathway

13.6

1.70E-03

32

Cytokine-cytokine receptor interaction

19.6

2.00E-09

 

NOD-like receptor signaling pathway

8.9

5.30E-05

 

Toll-like receptor signaling pathway

8.9

1.30E-04

  1. All top scorer clusters, with regard to indegree, outdegree and betweenness centrality metrics, were checked for enriched KEGG pathways.