The average VLDL performance of various subject groups. Green lines with round ends are normolipidemic subject groups. Groups indicated with darker green were used for the ROC curve in figure 3, those indicated with light green were not. Red lines with crosses represent dyslipidemic subject groups used for the ROC curve. Groups are labeled as follows: 1) hypothyroid patients during T4 treatment ; 2) subjects with small LDL peak size ; 3 and 8) mixed hyperlipidemia [24, 25]; 4) hypothyroid patients before treatment ; 5) kidney disease: membranous glomerulonephritis ; 6) patients on HIV treatment ; 7) kidney disease: focal segmental glomerulosclerosis . Blue lines with triangles indicate subject groups with specific genetic variant. FDB: Familial Defective ApoB (mostly heterozygote) ; FH: Familial Hypercholesterolemia (homozygote) ; S447X: specific single nucleotide polymorphism in the LPL gene .