Diagnostic markers based on a computational model of lipoprotein metabolism

Table 2 Comparison with results of first paper [13]

		Significance of inter-group difference	Significance of inter-group difference
	units	p-value [13]	p-value current
Size-specific process indicator parameters
Average particle lipolysis rate LDL	day^-1	0.026	N.S.
Average particle lipolysis rate VLDL2	day^-1	0.026	0.014
Average particle lipolysis rate VLDL1	day^-1	0.005	0.007
Average particle LPL lipolysis rate IDL	day^-1	N.S.	0.005
Average particle LPL lipolysis rate VLDL2	day^-1	N.S.	0.006
Average particle LPL lipolysis rate VLDL1	day^-1	N.S.	0.006
Average particle uptake rate LDL	day^-1	0.042	0.052
Average particle uptake rate IDL	day^-1	N.S.	0.042
Average particle HL attachment rate LDL	day^-1	0.026	N.S.
Average particle HL attachment rate VLDL2	day^-1	0.034	N.S.
Size and age parameters
Average particle age LDL	hours	0.014	0.031
Average particle age IDL	hours	N.S.	0.033
Average particle age VLDL2	hours	0.026	0.025
Average particle age VLDL1	hours	0.026	0.022
Average particle diameter LDL	nm	0.027	0.089
Average particle diameter IDL	nm	0.039	0.026
Average particle diameter VLDL1	nm	N.S.	0.045

Significance of difference between groups with lipoprotein phenotypes A (LDL peak size < 25 nm), I (25 nm < LDL peak size < 26 nm) and B (LDL peak size > 26 nm) from [18] for size-specific indicator parameters. The results from the further developed and calibrated model versus the original model from are shown [13]. Only those processes that show a significant difference (p < 0.1) using the nonparametric Kruskal-Wallis test are included.