Combined study of transcriptomics and metabolomics in atherosclerosis and liver inflammation induced by high fat diet in ApoE*3 Leiden mice. ApoE*3Leiden mice were treated with high cholesterol diets (HC), scored early atherosclerosis and profiled the pathophysiological state of the liver by using transcriptomics and metabolomics techniques. In HC group, the livers of mice switched from a resilient state to an inflammatory, pro-atherosclerotic state and developed atherosclerosis. HC-evoked changes were regulated by transcriptional master regulators. These regulators control both lipid metabolism and inflammation, and thereby link the two processes.