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Table 3 List of identified proteins with their accession numbers, theoretical and experimental molecular weights, pIs,

From: Proteome analysis of bronchoalveolar lavage in pulmonary langerhans cell histiocytosis

No. of spot

Protein name

AC

Theoretical

pI/Mr (KDa)

Experimental

pI/Mr (KDa)

Mascot search result

Mean %V ± SD × 10-4

1-way ANOVA p value

Folds in

Localization

     

No. of matched peptide

Sequence coverage (%)

Score

nsc

sc

PLCH

 

Nsc-sc

Nsc-PLCH

Sc-PLCH

 

PLCH > nsc and/or sc

               

1

Kininogen-1, fragment N-term

P01042

6.34

4.95

11

18

118

543±105§

225±214¥

5393±1864¥§

8.97E-06

2.41

9.93§

23.96Â¥

Secreted-extracellular space

   

72996

61092

           

2

Ig alpha-1 chain C region

P01876

6.08

5.98

8

25

116

879±788§

206±207¥

3179±1685¥§

0,002

4.26

3.61§

15.43Â¥

Secreted

   

38486

60221

           

3

Pigment epithelium

P36955

5.97

5.61

8

24

111

405±176§

281±87¥

1230±693¥§

0,007

1.44

3.03§

4.37Â¥

Secreted

   

46484

49075

           

4

Pigment epithelium

P36955

5.97

5.69

8

21

114

326±211§

307±182¥

767±260¥§

0,009

1.06

2.35§

2.49Â¥

Secreted

   

46484

49222

           

5

Haptoglobin, fragment c-term.

P00738

6.13

5.26

12

31

114

446±69§

432±180¥

2062±1186¥§

0,003

1.03

4.62§

4.77Â¥

Plasma

   

45861

40355

           

6

Creatine kinase B-type

P12277

5.34

5.31

7

26

108

267±146§

161±93¥

749±306¥§

0,001

1.65

2.80§

4.65Â¥

Cytoplasm

   

42902

41841

           

7

Annexin A3

P12429

5.63

5.59

8

32

111

158±159§

127±54¥

530±318¥§

0,017

1.24

3.35§

4.17Â¥

Cytoplasm

   

36524

31681

           

8

Alpha-1 anti tripsin

P01009

5.37

4.84

15

46

212

1491±1178§

299±413¥

5425±817¥§

1,79E-06

4.98

3.63§

18.14Â¥

Plasma

   

46878

53626

           

9

Alpha-1 anti tripsin

P01009

5.37

4.8

8

27

107

495 ± 979§

28 ± 64¥

2644 ± 1473¥§

0,003

17.6

5.34§

94.42Â¥

Plasma

   

46878

54359

           

10

Ceruloplasmin

P00450

5.44

5.1

11

13

134

135±118§

154±149¥

496±121¥§

0,001

1.14

3.67§

3.22Â¥

Plasma

   

122983

131973

           

11

Alpha-1-antitrypsin

P01009

5.37

4.96

13

41

175

288±221§

423±204¥

1359±551¥§

0,001

1.46

4.71§

3.21Â¥

Plasma

   

46878

58032

           

12

Serotransferrin

P02787

6.81

6.05

8

11

102

415±322§

162±219¥

2655±1223¥§

0,0003

2.56

6.39§

16.38Â¥

Plasma

   

79280

60048

           

13

Serotransferrin

P02787

6.81

6

11

19

112

623±170§

672±576¥

3255±2316¥§

0,016

1.07

5.22§

4.84Â¥

Plasma

   

79280

80091

           

14

Pyruvate kinase isozymes

P14618

7.96

6.47

11

28

105

276±236§

642±290¥

1391±596¥§

0,003

2.32

5.03§

2.16Â¥

Cytoplasm-Nucleus

   

58470

58174

           

15

Apolipoprotein A-I

P02647

5.56

5.03

8

26

99

179±103§

276±197¥

924±371¥§

0,0009

1.54

5.16§

3.34Â¥

Plasma

   

30759

23065

           

16

Hemoglobin subunit beta

P68871

6.75

6.77

11

77

155

109 ± 131§

328 ± 123¥

650 ± 233¥§

0,001

3

5.96§

1.98Â¥

Blood

   

16102

11120

           

17

Ceruloplasmin

P00450

5.44

5.13

15

18

123

259±183§

180±179¥

564±99¥§

0,005

1.43

2.17§

3.13Â¥

Plasma

   

122983

130654

           

18

Alpha-1-antitrypsin

P01009

5.37

4.7

11

32

143

277±290

93±77¥

599±288¥

0,018

2.97

2.16

6.44Â¥

Plasma

   

46878

50566

           

19

Actin, cytoplasmic 1

P60709

5.29

5.07

9

28

107

867±437

320±272¥

1071±348¥

0,016

2.7

1.23

3.34Â¥

Cytoskeleton

   

42052

40664

           

20

Ceruloplasmin

P00450

5.44

5.16

10

11

101

306±223

201±151¥

537±137¥

0,02

1.52

1.75

2.67Â¥

Plasma

   

122983

130000

           

21

Serotransferrin

P02787

6.81

6.07

16

22

166

1085±228§

1831±559

4471±2939§

0,022

1.68

4.12§

2.44

Plasma

   

79280

80.091

           

22

Serotransferrin

P02787

6.81

6.14

18

23

188

2376±300§

3235±879

4969±1743§

0,01

1.36

2.09§

1.53

Plasma

   

79280

79397

           

23

Fibrinogen gamma chain

P02679

5.37

5.52

10

28

133

511±354§

766±671

2649±2055§

0,039

1.49

5.18§

3.45

Plasma

   

52106

53481

           

24

Alpha-1-antitrypsin

P01009

5.37

5.29

8

27

121

197±222§

641±651

1938±1200§

0,01

3.25

9.83§

3.02Â¥

Plasma

   

46878

54009

           
  1. Mascot search results, mean and standard deviations, statistical p values and number of folds of protein expression in the three groups. Statistical significant differences between smoking controls (sc) and no-smoking controls (nsc) are visualized by *, statistical differences between smoking controls and Pulmonary Langerhans cell Histiocytosis (PLCH) are visualized by ¥and significant differences occurring between no-smoking controls and Pulmonary Langerhans cell Histiocytosis are shown by §. The proteins quantitatively more abundant in PLCH than in non-smoker and/or smoker control samples are reported in table 3.