Proteome analysis of bronchoalveolar lavage in pulmonary langerhans cell histiocytosis

Table 4 Proteins down-regulated in PLCH compared to non-smoker and/or smoker controls.

No. of spot	Protein name	AC	Theoretical pI/Mr (KDa)	Experimental pI/Mr (KDa)	Mascot search result			Mean %V ± SD × 10^-4			1-way ANOVA pvalue	Folds in			Localization
					No. of matched peptide	Sequence coverage (%)	Score	nsc	sc	PLCH		Nsc-sc	Nsc-PLCH	Sc-PLCH
PLCH < nsc and/or sc
25	Polymeric immunoglobulin receptor	P01833	5.58	5.14	10	18	129	2901±438^§	3037±1038^¥	911±694^¥§	1.31E-03	1.04	3.18^§	3.33^¥	Cell membrane
			84429	87377
26	Thioredoxin	P10599	4.82	4.67	6	40	82	665±113	1492±819^¥	230±235^¥	0,005	2.24	2.89	6.48^¥	Cytoplasm-Secreted
			12015	12098
27	Plastin-2	P13796	5.2	5.19	10	21	102	873±355	1272±320^¥	453±386^¥	0,01	1.45	1.92	2.80^¥	Cytoplasm-Cytoskeleton-Cell junktion
			70815	61983
28	Serum albumin	P02768	5.92	6.04	8	14	92	1830±647	2980±827^¥	1239±1363^¥	0,04	1.62	1.47	2.40^¥	Plasma
			71317	57513
29	Serum albumin, fragment	P02768	5.92	6.09	6	9	74	278±137	405±224^¥	124±83^¥	0,049	1.45	2.24	3.26^¥	Plasma
	N-term		71317	31059
30	ADP-ribosylation factor-like protein 3	P36405	6.74	7.37	6	52	107	305±161	621±331^¥	142±49^¥	0,012	2.03	2.14	4.37^¥	Membrane
			20614	21404
31	Alpha-1B-glycoprotein	P04217	5.58	5.16	8	22	109	1370±414^§	1163±443	663±83^§	0,022	1.17	2.06^§	1.75	Plasma
			54809	75685