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Figure 2 | Journal of Clinical Bioinformatics

Figure 2

From: Elucidating the identity of resistance mechanisms to prednisolone exposure in acute lymphoblastic leukemia cells through transcriptomic analysis: A computational approach

Figure 2

Flowcharts of the hypotheses posed for resistance. Simplified flowcharts (a) - (d) of the hypotheses posed for inherent or acquired resistance in ALL cells. Subsets S1 ∩ S3, D1 ∩ D3 and U1 ∩ D3 follow flowchart (a), subsets U1 ∩ U3 and D1 ∩ U3 follow flowchart (b), subsets S4 ∩ S5, U4 ∩ U5, U4 ∩ D5 and D4 ∩ U5 follow flowchart (c), and subset D4 ∩ D5 follows flowchart (d). Sets S i , U i , and D i include genes constantly expressed, up-regulated, and down-regulated in case i, respectively, where subscript i is varying from 1 to 5, and refers to each experimental setup. Each subset is tested for its GO enrichments, while gene functions are categorized as F a , F p , where F a is related to apoptosis induction and cell cycle arrest and F p is related to apoptosis evasion and cell cycle proliferation.

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Journal of Clinical Bioinformatics

ISSN: 2043-9113