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Table 1 Marker Concentration Changes

From: The impact of sample storage time on estimates of association in biomarker discovery studies

Date of sample collection

Concentration measured

% change

 

at sample collection

Sept 2009

 
 

CA 15-3

  

Nov 1997

166

187

12.65

Oct 1998

29

33

13.79

Apr 1995

10

12

20.00

Feb 2001

21

19

-9.52

Apr 2001

23

24

4.35

Feb 1999

33

34

3.03

Sep 2000

26

33

26.92

Sep 2000

24

33

37.50

Sep 2000

15

17

13.33

Sep 2000

12

16

33.33

Nov 1999

884

986

11.54

 

CA125

  

Feb 1999

83

96

15.66

Feb 1999

< LOD†

< LOD

 

Feb 1999

< LOD

< LOD

 

Feb 1999

51

69

35.29

Feb 1999

< LOD

< LOD

 

Sep 2000

77

73

-5.19

Sep 2000

33

32

-3.03

Sep 1998

106

105

-0.94

Oct 1998

1273

2026

59.15

  1. † LOD = limit of detection
  2. Concentrations of two markers, CA 15-3 and CA125, measured at the time of freezing and then again after a long term storage. Measurements with concentrations below the limit of detection were excluded from further analysis.