Figure 1

Dynamic of tumour growth and metastasis formation in the MS-model. Tumour development and number of disseminated cells at different steps of the simulation as a function of time. The calculations were done for a real hepatocellular carcinoma; maximal reachable tumour size and growth rate was originally fitted by the IKS-model with a Gompertzian growth function. The rates for metastasis formation in the MS-model were adjusted to give the same number of visible colonies as the analytical solution of the IKS-model.