Comparison of the cumulated number of metastases in the MS- and GDR-model with the IKS-model. Cumulated number of metastases derived from the primary tumour and the 1st order metastases for the MS- and GDR-model with the analytical solution from IKS-model. The days 432 (lower band) and 632 (upper band) after diagnosis of the primary tumour were chosen, which occurred 678 days after the initiation of the tumour. The clinical data were initially fitted by IKS for a hepatocellular carcinoma following the Gompertzian growth function with a rate for metastasis formation proportional to V.663. To get an impression of the influence of the metastases from metastases formation the contribution of the 2nd order metastases is shown separately for the GDR-model in the lower left corner. The 2nd order metastases formation from MS is below the chosen range.