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Table 1 Probability and time of 1 st metastasis formation

From: A dynamic model for tumour growth and metastasis formation

 

MS-Model

GDR-Model

Dissemination from primary

Metastases growth characteristis

Single Cell size [103 µm3]

Metastasis Formation [%]

Mean time of 1st colonizing cell [months]

Metastasis Formation [%]

Mean time of 1st colonizing cell [months]

Prim.

Meta.

Visible at pT2

Visible at pT4

Before pT1

Visible at pT2

Visible at pT4

Before pT1

V

P

1

1

95.0

100.0

100.0

22.6

99.5

100.0

100.0

23.7

2

1

93.3

100.0

100.0

22.1

97.0

100.0

100.0

23.3

V2/3

P

1

1

36.6

100.0

100.0

27.5

48.2

100.0

100.0

28.3

2

1

32.3

100.0

100.0

27.5

40.5

100.0

100.0

28.1

1

0.5

41.2

100.0

100.0

23.9

60.7

100.0

100.0

24.7

A

1

1

10.6

87.9

100.0

16.2

5.5

22.7

71.6

13.4

2

1

9.5

79.6

100.0

17.1

5.8

24.2

89.1

14.1

1

0.5

10.3

90.5

100.0

14.5

6.0

25.2

77.7

11.9

V1/3

P

1

1

6.9

42.4

45.9

53.1

9.4

63.9

61.2

45.2

2

1

6.6

44.4

59.2

51.2

8.4

58.2

76.6

45.2

1

0.5

7.9

54.1

63.9

49.4

10.9

75.4

80.3

40.0

A

1

1

4.0

17.3

98.1

29.5

2.5

6.1

15.2

22.7

2

1

4.5

17.2

99.3

30.7

3.5

7.9

22.1

23.6

1

0.5

5.0

20.2

99.8

25.8

3.5

8.7

19.9

19.6