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Table 4 Biological functions identified from IPA using overlapπng hub gene lists of SRF 50 and the published sets in the GB, BC and OC datasets

From: Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes

Cancer

Gene

Function

GB

RB1, πK3R1

cell morphology, hematological system development and function

 

PDGFBB, ERK1/2

tumor morphology, nervous system development and function

BC

ESR1,NFkB

developmental disorder, reproductive system disease, cellular growth and proliferation;

 

MYC

cancer, infection mechanism, gene expression and tumor morphology

 

ERK1/2

molecular transport, protein trafficking and cell cycle

OC

Akt

antigen presentation, cell-to-cell signaling and interaction, cellular growth and proliferation

 

FN1

tissue disorders, genetic disorder and cellular assembly and organization

 

NFkB

embryonic development and organismal development

 

PDGFBB

cardiac damage, organismal injury and abnormalities

 

ERK1/2

cell morphology, connective tissue development and function