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Table 1 Pathways enriched for non-synonymous SNPs in the TCGA data

From: High-prevalence and broad spectrum of Cell Adhesion and Extracellular Matrix gene pathway mutations in epithelial ovarian cancer

  Molecular Function/Pathway Enrichment Rank by p-value* Enrichment P-value (BH corrected) Enrichment level (observed/expected) Pathway mutational spectrum:% of genes Pathway Mutational Prevalence: % of tumors # genes mutated in at least 3 patients
KEGG ECM-receptor Interaction 1 3.35x10-11 ~4.5X 74% (62/84) 40% (127/316) 30
  Focal Adhesion 2 2.62x10-9 ~2.9X (61%) 122/199 58% (183/316) 45
  Calcium Signaling 3 2.05x10-8 ~2.9X 63% (112/179) 48% (153/316) 40
Gene Ontology Cell Adhesion 1 1.03x10-25 ~2.5X 64% (366/576) 89% (281/316) 156
  Developmental process 14 1.03x10-15 ~1.5X 49% (430/869) 90% (284/316) 375
  Extracellular Matrix 19 2.56x10-14 ~2.8X 53% (80/150) 40% (127/316) 76
  1. *Enriched pathways from all genes with predicted mutations in at least 3 ovarian tumors from the TCGA data were ranked by pvalue and selected pathways reported here.