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Table 1 Pathways enriched for non-synonymous SNPs in the TCGA data

From: High-prevalence and broad spectrum of Cell Adhesion and Extracellular Matrix gene pathway mutations in epithelial ovarian cancer

 

Molecular Function/Pathway

Enrichment Rank by p-value*

Enrichment P-value (BH corrected)

Enrichment level (observed/expected)

Pathway mutational spectrum:% of genes

Pathway Mutational Prevalence: % of tumors

# genes mutated in at least 3 patients

KEGG

ECM-receptor Interaction

1

3.35x10-11

~4.5X

74% (62/84)

40% (127/316)

30

 

Focal Adhesion

2

2.62x10-9

~2.9X

(61%) 122/199

58% (183/316)

45

 

Calcium Signaling

3

2.05x10-8

~2.9X

63% (112/179)

48% (153/316)

40

Gene Ontology

Cell Adhesion

1

1.03x10-25

~2.5X

64% (366/576)

89% (281/316)

156

 

Developmental process

14

1.03x10-15

~1.5X

49% (430/869)

90% (284/316)

375

 

Extracellular Matrix

19

2.56x10-14

~2.8X

53% (80/150)

40% (127/316)

76

  1. *Enriched pathways from all genes with predicted mutations in at least 3 ovarian tumors from the TCGA data were ranked by pvalue and selected pathways reported here.