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Table 2 Differentially expressed probes/genes in the setting of peripheral arterial disease

From: Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease

Upregulated Probe ID Gene name (HUGO) Gene symbol P-value FCA
219326_s_at UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 B3GNT2 0.032 1.53
205681_at BCL2-related protein A1 BCL2A1 0.008 1.73
215440_s_at brain expressed, X-linked 4 BEX4 0.004 1.50
1554229_at chromosome 5 open reading frame 41 C5orf41 0.004 1.51
202284_s_at cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A 0.024 1.62
208791_at clusterin CLU 0.029 1.84
208792_s_at clusterin CLU 0.038 1.83
226702_at cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial CMPK2 0.039 1.54
225557_at cysteine-serine-rich nuclear protein 1 CSRNP1 0.032 1.57
211919_s_at chemokine (C-X-C motif) receptor 4 CXCR4 0.039 1.59
208811_s_at DnaJ (Hsp40) homolog, subfamily B, member 6 DNAJB6 0.004 1.53
204751_x_at desmocollin 2 DSC2 0.007 1.68
226817_at desmocollin 2 DSC2 0.007 1.99
201044_x_at dual specificity phosphatase 1 DUSP1 0.043 1.94
209457_at dual specificity phosphatase 5 DUSP5 0.008 1.56
219872_at family with sequence similarity 198, member B FAM198B 0.003 1.51
207674_at Fc fragment of IgA, receptor for FCAR 0.012 1.99
211307_s_at Fc fragment of IgA, receptor for FCAR 0.012 1.72
221345_at free fatty acid receptor 2 FFAR2 0.007 2.34
209189_at FBJ murine osteosarcoma viral oncogene homolog FOS 0.01 1.70
213524_s_at G0/G1switch 2 G0S2 0.024 3.90
207387_s_at glycerol kinase GK 0.035 1.61
208524_at G protein-coupled receptor 15 GPR15 0.024 1.66
211555_s_at guanylate cyclase 1, soluble, beta 3 GUCY1B3 0.011 1.59
214455_at histone cluster 1, H2bg HIST1H2BG 0.041 1.88
1555464_at interferon induced with helicase C domain 1 IFIH1 0.026 1.55
211506_s_at interleukin 8 IL8 0.022 3.69
220266_s_at Kruppel-like factor 4 (gut) KLF4 0.034 1.61
208960_s_at Kruppel-like factor 6 KLF6 0.038 1.88
217738_at nicotinamide phosphoribosyltransferase NAMPT 0.027 1.73
217739_s_at nicotinamide phosphoribosyltransferase NAMPT 0.021 1.80
243296_at nicotinamide phosphoribosyltransferase NAMPT 0.008 2.00
203574_at nuclear factor, interleukin 3 regulated NFIL3 0.008 1.55
216015_s_at NLR family, pyrin domain containing 3 NLRP3 0.041 1.52
205660_at 2'-5'-oligoadenylate synthetase-like OASL 0.035 1.50
224102_at purinergic receptor P2Y, G-protein coupled, 12 P2RY12 0.022 1.56
201120_s_at progesterone receptor membrane component 1 PGRMC1 0.008 1.54
210845_s_at plasminogen activator, urokinase receptor PLAUR 0.004 1.60
211924_s_at plasminogen activator, urokinase receptor PLAUR 0.004 1.76
204285_s_at phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 0.005 1.52
202014_at protein phosphatase 1, regulatory (inhibitor) subunit 15A PPP1R15A 0.012 1.96
37028_at protein phosphatase 1, regulatory (inhibitor) subunit 15A PPP1R15A 0.008 1.87
1554997_a_at prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PTGS2 0.025 2.77
200730_s_at protein tyrosine phosphatase type IVA, member 1 PTP4A1 0.03 1.62
1569599_at SAM domain, SH3 domain and nuclear localization signals 1 SAMSN1 0.006 1.72
222088_s_at solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A14 0.033 1.56
215223_s_at superoxide dismutase 2, mitochondrial SOD2 0.038 1.57
205214_at serine/threonine kinase 17b STK17B 0.004 1.60
210190_at syntaxin 11 STX11 0.003 1.65
1552542_s_at T-cell activation RhoGTPase activating protein TAGAP 0.004 1.66
235086_at thrombospondin 1 THBS1 0.038 2.12
221060_s_at toll-like receptor 4 TLR4 0.025 1.82
206116_s_at tropomyosin 1 (alpha) TPM1 0.013 1.58
241133_at T cell receptor beta constant 1 TRBC1 0.048 1.91
Downregulated Probe ID Gene name (HUGO) Gene name P-value FCA
239661_at AF4/FMR2 family, member 1 AFF1 0.022 1.63
220467_at -- AL590452.1 0.043 1.56
236921_at -- AL592494.5 0.027 1.64
238807_at ankyrin repeat domain 46 ANKRD46 0.038 1.53
216198_at activating transcription factor 7 interacting protein ATF7IP 0.026 1.50
236307_at BTB and CNC homology 1, basic leucine zipper transcription factor 2 BACH2 0.039 2.11
236796_at BTB and CNC homology 1, basic leucine zipper transcription factor 2 BACH2 0.015 1.70
244172_at B-cell linker BLNK 0.043 1.78
227576_at BMP2 inducible kinase-like BMP2KL 0.048 1.83
244425_at chromosome 14 open reading frame 43 C14orf43 0.03 1.65
238635_at chromosome 5 open reading frame 28 C5orf28 0.00E+00 2.03
232330_at chromosome 7 open reading frame 44 C7orf44 0.046 1.58
239545_at CAS1 domain containing 1 CASD1 0.024 1.64
1564164_at DENN/MADD domain containing 1B DENND1B 0.048 1.53
230653_at DIS3 mitotic control homolog (S. cerevisiae)-like 2 DIS3L2 0.039 1.77
244876_at early B-cell factor 1 EBF1 0.034 1.50
230983_at family with sequence similarity 129, member C FAM129C 0.043 1.63
1563674_at Fc receptor-like 2 FCRL2 0.041 1.68
228623_at FTX transcript, XIST regulator (non-protein coding) FTX 0.048 1.82
1562289_at G protein-coupled receptor 141 GPR141 0.036 1.66
206785_s_at killer cell lectin-like receptor subfamily C, member 1 KLRC1 0.035 1.69
224559_at metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) MALAT1 0.032 1.68
243736_at methyltransferase like 15 METT5D1 0.034 1.59
232478_at MIR181A2 host gene (non-protein coding) MIR181A2HG 0.021 1.52
228623_at FTX transcript, XIST regulator (non-protein coding) FTX 0.048 1.82
243310_at -- -- 0.017 1.52
239673_at nuclear receptor subfamily 3, group C, member 2 NR3C2 0.037 1.94
240128_at 5'-nucleotidase, cytosolic III NT5C3 0.03 1.57
1559054_a_at protein phosphatase 1, regulatory (inhibitor) subunit 7 PPP1R7 0.004 1.60
238875_at RANBP2-like and GRIP domain containing 1 RGPD1 0.026 1.50
241838_at -- RP1-167A14.2 0.034 1.54
242239_at -- RP11-139J15.3 0.008 1.55
228390_at -- RP11-659G9.3001 0.033 1.57
213939_s_at RUN and FYVE domain containing 3 RUFY3 0.035 1.50
244267_at SATB homeobox 1 SATB1 0.025 1.81
236561_at transforming growth factor, beta receptor 1 TGFBR1 0.033 1.66
236427_at WW domain containing oxidoreductase WWOX 0.035 1.61
1556543_at zinc finger, CCHC domain containing 7 ZCCHC7 0.041 1.68
228157_at zinc finger protein 207 ZNF207 0.027 2.01
236562_at zinc finger protein 439 ZNF439 0.015 1.51
240155_x_at zinc finger protein 479 ZNF479 0.012 1.52
1558486_at zinc finger protein 493 ZNF493 0.012 1.53
  1. FCA = Fold change absolute
  2. -- = HUGO Gene Nomenclature Committee (HGNC) assigned unique gene name is not available