Table 6 Reactome molecular events enriched in upregulated genes

Platelet Activation

0.011

Formation of Platelet plug

0.015

Exocytosis of platelet alpha granule contents

0.016

Metabolism of water-soluble vitamins and cofactors

0.017

Chemokine receptors bind chemokines

0.021

Metabolism of vitamins and cofactors

0.022

Liganded Gi-activating GPCR acts as a GEF for Gi

0.023

The Ligand:GPCR:Gi complex dissociates

0.023

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

0.023

NFkB and MAP kinases activation mediated by TLR4 signaling repertoire

0.025

Hemostasis

0.027

MyD88-independent cascade initiated on plasma membrane

0.028

G alpha (i) signalling events

0.029

Class A/1 (Rhodopsin-like receptors)

0.030

Toll Like Receptor 10 (TLR10) Cascade

0.033

Toll Like Receptor 5 (TLR5) Cascade

0.033

MyD88 cascade initiated on plasma membrane

0.033

MyD88:Mal cascade initiated on plasma membrane

0.035

Toll Like Receptor TLR1:TLR2 Cascade

0.035

Toll Like Receptor TLR6:TLR2 Cascade

0.035

Toll Like Receptor 2 Cascade

0.035

Activated TLR4 signalling

0.040

Platelet degranulation

0.041

Toll Like Receptor 4 (TLR4) Cascade

0.042

Response to elevated platelet cytosolic Ca2+

0.046