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Table 6 Reactome molecular events enriched in upregulated genes

From: Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease

Reactome Pathway P-value
Platelet Activation 0.011
Formation of Platelet plug 0.015
Exocytosis of platelet alpha granule contents 0.016
Metabolism of water-soluble vitamins and cofactors 0.017
Chemokine receptors bind chemokines 0.021
Metabolism of vitamins and cofactors 0.022
Liganded Gi-activating GPCR acts as a GEF for Gi 0.023
The Ligand:GPCR:Gi complex dissociates 0.023
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi 0.023
NFkB and MAP kinases activation mediated by TLR4 signaling repertoire 0.025
Hemostasis 0.027
MyD88-independent cascade initiated on plasma membrane 0.028
G alpha (i) signalling events 0.029
Class A/1 (Rhodopsin-like receptors) 0.030
Toll Like Receptor 10 (TLR10) Cascade 0.033
Toll Like Receptor 5 (TLR5) Cascade 0.033
MyD88 cascade initiated on plasma membrane 0.033
MyD88:Mal cascade initiated on plasma membrane 0.035
Toll Like Receptor TLR1:TLR2 Cascade 0.035
Toll Like Receptor TLR6:TLR2 Cascade 0.035
Toll Like Receptor 2 Cascade 0.035
Activated TLR4 signalling 0.040
Platelet degranulation 0.041
Toll Like Receptor 4 (TLR4) Cascade 0.042
Response to elevated platelet cytosolic Ca2+ 0.046