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Table 6 Disease ontology terms associated with proteins involved in 3D domain swapping.

From: Functional repertoire, molecular pathways and diseases associated with 3D domain swapping in the human proteome

DO Term

Genes

P-value

Asthma

IL10, TJP1, BCL2L1, IL5

0.001

Amyotrophic lateral sclerosis

MET, DCTN1, CST3

0.001

Bronchial hyperreactivity

IL10, IL5

0.001

Pulmonary alveolar proteinosis

IL10, CST3

0.001

Dental plaque

IL10, TJP1, BCL2L1

0.002

Prostate cancer

IL10, NCOA2, GLO1, SERPINC1, CST3

0.002

Fatty liver

MET, IL10

0.003

Atherosclerosis

NOD1, IL10, EPHX2, CST3

0.003

Rabies

RNASE1, BCL2L1, SERPINC1

0.004

Parkinson disease

IL10, EPHX2, BCL2L1

0.004

Thyroid cancer

IL10, TJP1

0.023

Neoplasm metastasis

IL10, RNASE1, CST3

0.024

Hypertension

IL10, EPHX2, CST3

0.028

Breast cancer

IL10, NCOA2, CSTA, CST3

0.05

Lung cancer

IL10, CSTA, CSTB

0.057

Adenovirus infection

PTK2, BCL2L1

0.072

Abortion

NOD1, IL10

0.085

Autistic disorder

MET, GLO1

0.096

Kidney disease

PTK2, SERPINC1

0.101

Kidney failure

IL10, CST3

0.128

Enteritis

NOD1, IL10

0.142

Autoimmune disease

IL10, BCL2L1

0.148

Systemic scleroderma

MET, IL10

0.173

Ulcerative colitis

NOD1, IL5

0.18

Multiple sclerosis

GLO1, BCL2L1

0.184

Infection

NOD1, IL10

0.266

Dermatitis

CSTA, IL5

0.294

Cancer

MET, PTK2, EPHX2, BCL2L1

0.329

Lupus erythematosus

IL10, PTK2

0.378

Melanoma

IL10, TJP1

0.41

Alzheimer's disease

IL10, CST3

0.713

Embryoma

IL10, CST3

0.99

Rheumatoid arthritis

BCL2L1, CST3

0.99

Colon cancer

NOD1, TJP1

0.99

Leukemia

IL10, NCOA2

0.99

Diabetes mellitus

TJP1, CST3

0.99

  1. Statistically significant associations are highlighted in bold