Figure 5

The de novo modules (represented by module eigenpeptide, ME), are highly correlated to pathologically associated phenotypes. An illustration from the SARS dataset is shown. Clear patterns emerge showing positive and negative correlation clusters. As expected, related phenotypes such as airspace inflammation, interstitial septum inflammation, and diffuse alveolar damage tend to be correlated in the same direction showing an overarching biological process at work. Label Key: Alv.Par.Pneumonia: alveolar parenchyma pneumonia, DAD: diffuse alveolar damage, OverallTotalScore: cumulative score calculated by a pathologist.