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Table 2 Network topology may be useful for resolving degenerate peptide mappings

From: Protein co-expression network analysis (ProCoNA)

Data Peptides Proteins Mean TO RandomTO p-value
Sarcopenia 2845 685 0.089 0.004 2.09e-14
SARS 2008 707 0.025 0.004 2.2e-16
Influenza 989 493 0.028 0.005 8.99e-16
  1. Results from a two-sample t-test between topological overlap (TO) of peptides derived from the same protein versus peptides selected at random. This result statistically shows that the connectivity for a protein’s constituent peptides is far from random. Network topology may be useful for resolving cases of degenerate peptide mapping, increasing confidence in protein identification.