Protein co-expression network analysis (ProCoNA)

Table 2 Network topology may be useful for resolving degenerate peptide mappings

Data	Peptides	Proteins	Mean TO	RandomTO	p-value
Sarcopenia	2845	685	0.089	0.004	2.09e-14
SARS	2008	707	0.025	0.004	2.2e-16
Influenza	989	493	0.028	0.005	8.99e-16

Results from a two-sample t-test between topological overlap (TO) of peptides derived from the same protein versus peptides selected at random. This result statistically shows that the connectivity for a protein’s constituent peptides is far from random. Network topology may be useful for resolving cases of degenerate peptide mapping, increasing confidence in protein identification.