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Figure 1 | Journal of Clinical Bioinformatics

Figure 1

From: Using biomarkers to predict progression from clinically isolated syndrome to multiple sclerosis

Figure 1

Gene-expression profiles in subjects with CIS, MS-naïve or MS-established. (a) Expression levels of 23 target genes were determined by quantitative reverse-transcription PCR and normalized to expression of GAPDH. Results are expressed as the ratio of the expression level of the indicated genes in the disease cohort relative to the CTRL cohort, log2. Genes are identified that showed statistically significant (P < 0.05 after Bonferroni’s correction for multiple testing) increased (red boxes) or decreased (green boxes) expression. Numerical expression ratios, log2, of the test/CTRL cohorts are displayed within the boxes. (b) Cumulative percentage of over- and under-expressed genes in each disease cohort relative to CTRL. (c) Statistical significance of the expression level of each target gene between each disease cohort and CTRL was determined using Student’s T test. P values are expressed as log10.

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