Figure 3
From: A systematic analysis of a mi-RNA inter-pathway regulatory motif
mTOR signaling pathway (#hsa04150). TOR signaling pathway (#hsa04150) including the identified PPL (3/31/09 release). (1) The pathway host-gene (RSK) expresses a protective intragenic miRNA (miR-1976) which (2) acts against the expression of the MLL transcription factor. (3) MLL is responsible for HOXA9 transcription, that (4) leads to the expression of miR-196b which, if expressed, (5) would target RICTOR, dysregulating the mTORC2 complex in which RICTOR plays a central role.