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Table 1 Human CBE gene expression profiles for ion channels implicated in AH production

From: In silicoanalysis of the molecular machinery underlying aqueous humor production: potential implications for glaucoma

Ion channel

Gene name

NPE

PE

SIG

Water channel

AQP1 *

H

H

 

AQP2

M

M

 

AQP5

L

M

 

AQP11 *

M

M

 

Na+/K+ ATPase

ATP1A1 *

H

H

 

ATP1A2 *

H

H

 

ATP1A3

M

M

 

ATP1A4

M

M

 

ATP1B1 *

H

H

PE

ATP1B2 *

H

H

 

ATP1B3 *

H

H

 

Cl- channel

CLCN2

L

M

 

CLCN3

M

M

 

CLCN6

M

M

 

CLCN7

M

M

 

CLIC1 *

H

H

 

CLIC2

L

M

 

CLIC4 *

H

H

 

CLIC6 *

M

H

 

Gap junction

GJA1 *

H

H

 

GJA4 *

M

M

PE

K+ channel

KCNA5 *

L

M

 

KCNAB1

M

M

 

KCNB1

M

M

 

KCNB2 *

L

M

PE

KCND2 *

L

M

PE

KCND3 *

M

M

 

KCNE1

M

M

 

KCNE3

H

M

 

KCNE4

L

M

 

KCNG1

M

M

 

KCNJ12

M

M

 

KCNJ13 *

H

H

 

KCNJ14

M

M

 

KCNJ2

M

M

 

KCNJ8 *

M

M

 

KCNK1

M

M

 

KCNK13

M

M

 

KCNK15

M

M

 

KCNK3

M

L

 

KCNK4

L

M

 

KCNK7

M

M

 

KCNQ1 *

M

M

 

KCNS3 *

M

M

 

KCNV2

M

M

 

Na+ channel

SCN2B

M

M

 

SCN3B

M

M

 

SCN4B *

H

H

 

Na+/2Cl-/K+ co-transport

SLC12A2

M

M

 

Cl-/HCO3- exchanger

SLC4A2 *

L

M

 

SLC4A3

M

M

 

Na+/HCO3- symport

SLC4A4

M

M

 

SLC4A7

M

M

 

Na+/H+ exchanger

SLC9A5

M

M

 

SLC9A6

M

L

 
 

SLC9A9

M

M

 
  1. Expression profiles of genes coding for ion channels implicated in aqueous humor (AH) production in healthy human non-pigmented (NPE) or pigmented epithelium (PE) of the ciliary body. The list of ion-channels involved in AH production is from Civan et al., 2004. We ranked the genes by expression level and assigned percentile ranks (P). Next, we formed four groups: high (H) expression (expression >90th P), moderate (M) expression (50-90th P), low (L) expression (10-50th P) and very low (VL) expression (<10th P). We also compared the NPE and PE expression data and indicated if genes were signature genes (SIG) of an epithelial cell layer (p-value < 0.01 and fold change >2.5). In this table, we only presented genes with moderate or high expression level in at least one epithelial layer. The total list of ion-channels and gene expression profiles is presented in Additional file 1: Table S1. Genes indicated with * are also present in Transport sub-dataset and indicated in Figure 2.