Improved branch and bound algorithm for detecting SNP-SNP interactions in breast cancer

Table 2 Estimated best combinations of SNPs on the occurrence of breast cancer in the high risk group

Combined SNP number (specific SNPs)	SNP Genotypes	Control number / Case number	CC	SN	SP	Average	Odds Ratio (CI)	p-value
Two SNPs	Other	330/209
SNPs (4, 7)	2-3	4/11	0.615	0.050	0.988	0.551	4.342 (1.259-16.934)	0.013
		(Diff. = 7)
Three SNPs	Other	314/191
SNPs (3, 5, 6)	2-1-1	20/29	0.619	0.132	0.940	0.564	2.384 (1.263-4.518)	0.005
		(Diff. = 9)
Four SNPs	Other	325/203
SNPs (3, 4, 5, 6)	2-1-1-1	9/17	0.617	0.077	0.973	0.556	3.024 (1.246-7.491)	0.008
		(Diff. = 8)
Five SNPs	Other	329/210
SNPs (1, 3, 4, 5, 6)	1-2-1-1-1	5/10	0.612	0.045	0.985	0.547	3.133 (0.969-10.680)	0.031
		(Diff. = 5)
Six SNPs	Other	332/214
SNPs (1, 2, 3, 5, 6, 7)	1-2-2-1-1-2	0/4	0.610	0.018	1.000	N.E
		(Diff. = 4)
Seven SNPs	Other	333/216
SNPs (1, 2, 3, 4, 5, 6, 7)	2-2-2-1-1-1-1	1/4	0.608	0.014	0.997	0.540	6.167 (0.648-145.871)	0.084
		(Diff. = 3)

^{NOTE -} Other: The reference group, indicating the union of all other possible two to seven SNP combinations; N.E: Not estimable; CC: Correct; SN: Sensitivity; SP: Specificity.