Table 2 The effects of miRNA on target molecules
Target molecule in cancer | miRNA involved | Effects on target molecule |
|---|---|---|
SIRT1/HDAC III | miR-34a, miR-22, miR-499, miR-200, mi-9, miR-181a, miR-181b, miR-204, miR-199b, miR-135 | Down-regulated |
p53 | miR-34a | Upregulated |
EMT | miR-200 | Down-regulated |
DNMT | miR-148, miR-29a, miR-29b, miR-29c | Overexpression of DNMTs |
EZH2 histone lysine methyltransferase | miR-101 | Upregulated and causes drug resistance in breast cancer |
ER expression | miR-101, miR-206, miR-221/222 | Down-regulated |
p21 | miR-34a | Upregulated |