Table 1 Enriched pathways in disjoint catalog analysis
| Â | Human | Mouse | ||
|---|---|---|---|---|
| Â | Cross-alignment | Cross hybridization | Cross-alignment | Cross hybridization |
1 | Cytoskeleton remodeling: keratin filaments | Protein folding and maturation: POMC processing | Cytoskeleton remodeling: neurofilaments | Neurophysiological process: Dopramine D2 receptor transactivation of PDGFR in CNS |
2 | Signal transduction: cAMP signaling | Normal and pathological: TGF-beta mediated regulation of cell proliferation | DNA damage: ATM/ATR regulation of G2M checkpoint | Transcription role of heterochromatin protein 1 (HP1) family in transcriptional silencing |
3 | Development: regulation of epithelial to mesenchymal transition (EMT) | Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling | Cell cycle: role of Nek in cell cycle regulation | Development: hedgehog and PTH signaling pathways in bone and cartilage development |
4 | Cell adhesion: gap junctions | Signal transduction, Erk interaction: inhibition of Erk | Cell cycle: spindle assembly and chromosome separation | Cytoskeleton remodeling: neurofilaments |
5 | Development: transcription regulation of granulocyte development | Development: melanocyte development ang pigmentation | Development: hedgehog signaling | Development: Gastrin in differentiation of the gastric mucosa |
6 | Cytoskeleton remodelling: regulation of actin cytoskeleton by Rho GTPases | Translation: non-genomic (rapid) action of androgen receptor | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | Blood coagulation: Blood coagulation |
7 | Cell adhesion: Histamine H1 receptor signlaing in the interruption to cell barrier integrity | G-protein signaling : Rap1A regulation pathway | Development: FGFR signaling pathway | Development thrombopotein-regulated cell processes |
8 | Development: beta-adrenergic receptors signaling via cAMP | Development: GDNF family signaling | Muscle contraction: regulation of eNOS activity in endothelial cells | Neurophysiologiacal process: ACM regulation of nerve impulse |
9 | Cytoskeleton remodeling: reverse signaling by Ephrin B | DNA damage: role of SUMO in p53 regulation | GFTR folding and maturation (normal and CF) | Development: WNT5 signaling |
10 | Regulation of lipid metabolism: regualtion of lipid metabolism by niacin and isoprenaline | Muscle contaction: relaxin signaling pathway | DNA damage: role of SUMO in p53 regulation | Transport: Alpha-2 energenic receptor regulation of Ion channels |