Table 2 Enriched pathways in CCDS analysis
| Â | Human | Mouse | ||
|---|---|---|---|---|
| Â | Cross-alignment | Cross hybridization | Cross-alignment | Cross hybridization |
1 | Development: regulation of epithelial to mesenchymal (EMT) | Protein folding and maturation: POMC processing | Cell cycle: role of Nek in cell cycle regulation | Signal transduction: activin A signaling regulation |
2 | Cytoskeleton remodeling: Keratin filaments | Normal and pathological TGF-beta mediated regulation of cell proliferation | Cell cycle: the methaphase checkpoint | Transcription role of heterochromatin protein 1 (HP1) family in trancriptional silencing |
3 | Cardia hypertrophy NF-AT signaling in cardia hypertrophy | Signal transduction, Erk interactions: inhibition of Erk | Cytoskeleton remodeling: neurofilaments | Cytoskeleton remodeling: neurofilaments |
4 | Cell adhesion: gap junctions | Development: melaconyte development and pigmentation | ATP metabolism | Dvelopment: thrombopoietin regulated cell process |
5 | Cell adhesion: hestamine H1 receptor signaling in the interruption of cell barrier integrity | Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling | Cell cycle: spindle assembly and chromosome separation | Neurophysiological process nNOS signaling in neronal synapases |
6 | Signal transduction: cAMP signaling | Develeopment A2A receptor signaling | dCTP/dUTP metabolism | Development: role of HDAC and calcium/calmodulin dependent kinase (CaMK) in control of skeletal of myogenesis |
7 | Immune response: MIF-neuroendocrine macrophage connector | Development transcription regulation of granulocyte development | Apoptosis and survival: DNA damage induced apoptosis | Protein folding: membrane trafficking and signal transduction of G-alpha heterotrimeic G-protein |
8 | Development transcription: regulation of grabulocyte development | Cytoskeleton remodeling Alpha-1A andrenergic recepto- dependent inhibition of PI3K | Transcription: androgen receptor nuclear signaling | Development: role of activin A in cell differentiation and proliferation |
9 | Cell adhesion: edothelial cell contacts by junctional mechanisms | Muscle contraction: relaxin signaling pathway | Neurophysiological process: ACM regulation of nerve impulse | Development: WNT5A signaling |
10 | Atherosclerosis: role of ZNF202 in regulation of expression of genes involved in Atherosclerosis | Immune response: lectin induced complement pathway | Development WNT signaling pathway | Development: PIP3 signaling in cardiac myocytes |