Table 8 Down-deleted genes

CASP1 and LAMA3

regulate cell adhesion

MSX2

blocks cell proliferation)

SFRP2

(is a tumor suppressor gene

frequently methylated in CRC)

Stage2 vs stage3

Gene

Function

GAS1 and KLK6, FAM3B

induce apoptosis

LRP4

a negative regulator of WNT

signaling pathway

PITX2

is a regulator of beta-catenin

signaling

Stage3 vs stage4

Gene

Function

SLIT2

is a positive regulator of

apoptosis and blocks migration

TIMP3

is involved in p53

signaling pathway,

MLF1

induces cell cycle arrest