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Table 1 Lists of metabolites differentially expressed among the patients (MI) and healthy volunteers (HT)

From: Metabolomics and partial least square discriminant analysis to predict history of myocardial infarction of self-claimed healthy subjects: validity and feasibility for clinical practice

Class of metabolite

Metabolite

p -value ( p = 0.005)

Log fold change

AUC

Sensitivity

Specificity

Lipids

8,11,14-nonadecatriynoic acid

3.72E-11

-13.01

0.727

0.8

0.8

 

18-oxo-nonadecanoic acid

1.17E-05

-3.30

0.691

0.8

0.6

 

5,8-heptadecadiynoic acid

1.28E-18

-4.29

0.754

0.9

0.7

 

19-methyl-heneicosanoic acid

4.37E-08

-2.78

0.680

0.7

0.5

 

Methyl 12,13-epoxy-9,15-octadecadienoic acid

4.61E-05

1.14

0.776

0.7

0.7

 

5,8,11,14-Docosatetraynoic acid

7.49E-10

1.44

0.861

0.8

0.8

 

2E,5Z,8Z,11Z,14Z-eicosapentaenoic acid

4.66E-06

5.20

0.909

0.8

0.8

 

14-methyl-8-hexadecen-1-ol

1.07E-07

5.52

0.689

0.5

0.8

 

15(S)-HETE

6.18E-15

11.04

0.997

1.0

1.0

 

Prostaglandin E2

2.58E-06

2.86

0.910

0.8

0.9

 

Vitamin K1 2,3-epoxide

1.11E-05

1.74

0.679

0.6

0.8

 

24,25-Dihydroxyvitamin D

3.48E-06

-2.07

0.874

0.8

0.8

 

21-Deoxycortisol

3.97E-09

-2.90

0.688

0.7

0.7

 

C22 Sulfatide

7.06E-11

-8.73

0.766

0.8

0.8

 

1-(9Z-heptadecenoyl)-2-docosanoyl-sn-glycerol

2.33E-03

-1.95

0.655

0.8

0.5

 

1-(9Z,12Z-heptadecadienoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol

1.72E-04

2.63

0.681

0.8

0.7

 

Phosphorylcholine

5.31E-17

14.04

0.995

1.0

1.0

 

GPCho(16:1(9E)/0:0)

1.61E-05

5.22

0.737

0.9

0.6

 

GPCho(16:1(9Z)/2:0)

3.39E-05

1.96

0.881

0.8

0.8

 

GPCho(O-18:1(9Z)/0:0)

2.10E-04

2.23

0.869

0.8

0.8

Others

Indoleacetaldehyde

4.05E-07

-5.96

0.751

0.9

0.8

 

Inosine

1.20E-04

-4.85

0.652

0.6

0.9

 

Biliverdin IX

1.83E-06

-3.51

0.665

0.8

0.6

 

L-Urobilinogen

1.48E-05

5.32

0.635

0.8

0.8

  1. Significant analysis was performed using t-test unequal variance (p<0.005). The (-) Fold change value indicates the down regulation of the metabolite in MI, while (+) fold change value indicates the up regulation of metabolite in the MI when compared to HT.