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  1. Content type: Review

    Reversible protein phosphorylation is one of the most important forms of cellular regulation. Thus, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool to evaluate cell functional ...

    Authors: Elena López, Jan-Jaap Wesselink, Isabel López, Jesús Mendieta, Paulino Gómez-Puertas and Sarbelio Rodríguez Muñoz

    Citation: Journal of Clinical Bioinformatics 2011 1:26

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  2. Content type: Research

    The excision repair cross-complementation group 1 (ERCC1) protein is the key enzyme of the nucleotide excision repair (NER) pathway. Loss of protein expression on immunohistochemistry is predictive for platinu...

    Authors: Alex Soltermann, Sandra Kilgus-Hawelski, Silvia Behnke, Martina Storz, Holger Moch and Beata Bode

    Citation: Journal of Clinical Bioinformatics 2011 1:25

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  3. Content type: Review

    The aim of the overview is to give a perspective of global biobank development is given in a view of positioning biobanking as a key resource for healthcare to identify new potential markers that can be used i...

    Authors: Ákos Végvári, Charlotte Welinder, Henrik Lindberg, Thomas E Fehniger and György Marko-Varga

    Citation: Journal of Clinical Bioinformatics 2011 1:24

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  4. Content type: Research

    Large cell neuroendocrine carcinoma (LCNEC) of the lung, a subtype of large cell carcinoma (LCC), is characterized by neuroendocrine differentiation that small cell lung carcinoma (SCLC) shares. Pre-therapeuti...

    Authors: Masaharu Nomura, Tetsuya Fukuda, Kiyonaga Fujii, Takeshi Kawamura, Hiromasa Tojo, Makoto Kihara, Yasuhiko Bando, Adi F Gazdar, Masahiro Tsuboi, Hisashi Oshiro, Toshitaka Nagao, Tatsuo Ohira, Norihiko Ikeda, Noriko Gotoh, Harubumi Kato, Gyorgy Marko-Varga…

    Citation: Journal of Clinical Bioinformatics 2011 1:23

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  5. Content type: Database

    Large multi-center clinical studies often involve the collection and analysis of biological samples. It is necessary to ensure timely, complete and accurate recording of analytical results and associated pheno...

    Authors: Prakash M Nadkarni, Rowena Kemp and Chirag R Parikh

    Citation: Journal of Clinical Bioinformatics 2011 1:22

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  6. Content type: Research

    Advanced stage head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with low survival rates. Loss-of-heterozygosity/allelic imbalance (LOH/AI) analysis has been widely used to identify genomic...

    Authors: Gurkan Bebek, Mohammed Orloff and Charis Eng

    Citation: Journal of Clinical Bioinformatics 2011 1:21

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  7. Content type: Research

    The rapidly growing amount of array CGH data requires improved visualization software supporting the process of identifying candidate cancer genes. Optimally, such software should work across multiple microarr...

    Authors: Malte Mader, Ronald Simon, Sascha Steinbiss and Stefan Kurtz

    Citation: Journal of Clinical Bioinformatics 2011 1:20

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  8. Content type: Short report

    Allogenic hematopoietic stem cell transplantation is a curative treatment for patients with advanced hematologic malignancies. However, the long-term mental health issues of siblings who were not selected as d...

    Authors: Morihito Takita, Yuji Tanaka, Yuko Kodama, Naoko Murashige, Nobuyo Hatanaka, Yukiko Kishi, Tomoko Matsumura, Yukio Ohsawa and Masahiro Kami

    Citation: Journal of Clinical Bioinformatics 2011 1:19

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  9. Content type: Methodology

    Massive datasets comprising high-resolution images, generated in neuro-imaging studies and in clinical imaging research, are increasingly challenging our ability to analyze, share, and filter such images in cl...

    Authors: Teeradache Viangteeravat, Matthew N Anyanwu, Venkateswara Ra Nagisetty and Emin Kuscu

    Citation: Journal of Clinical Bioinformatics 2011 1:18

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  10. Content type: Research

    The mitogen activated protein kinase (MAPK) pathways are known to be deregulated in many human malignancies. Phosphopeptide identification of protein-kinases and site determination are major challenges in biom...

    Authors: Elena López, Isabel López, Julia Sequí and Antonio Ferreira

    Citation: Journal of Clinical Bioinformatics 2011 1:16

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  11. Content type: Research

    miRNAs are a class of small RNAs that regulate gene expression via RNA silencing machinery. Some viruses also encode miRNAs, contributing to the complex virus-host interactions. A better understanding of viral...

    Authors: Guangchuang Yu and Qing-Yu He

    Citation: Journal of Clinical Bioinformatics 2011 1:15

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  12. Content type: Research

    To identify non-invasive gene expression markers for chronic obstructive pulmonary disease (COPD), we performed genome-wide expression profiling of peripheral blood samples from 12 subjects with significant ai...

    Authors: Soumyaroop Bhattacharya, Shivraj Tyagi, Sorachai Srisuma, Dawn L DeMeo, Steven D Shapiro, Raphael Bueno, Edwin K Silverman, John J Reilly and Thomas J Mariani

    Citation: Journal of Clinical Bioinformatics 2011 1:12

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  13. Content type: Research

    Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

    Authors: In-Hee Lee, Gerald H Lushington and Mahesh Visvanathan

    Citation: Journal of Clinical Bioinformatics 2011 1:11

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  14. Content type: Review

    Adaptor proteins, with multi-modular structures, can participate in the regulation of various cellular functions. During molecular cloning process of actin filament associated protein, we have discovered a nov...

    Authors: Atsushi Shiozaki and Mingyao Liu

    Citation: Journal of Clinical Bioinformatics 2011 1:10

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  15. Content type: Methodology

    Using serum, plasma or tumor tissue specimens from biobanks for biomarker discovery studies is attractive as samples are often readily available. However, storage over longer periods of time can alter concentr...

    Authors: Karl G Kugler, Werner O Hackl, Laurin AJ Mueller, Heidi Fiegl, Armin Graber and Ruth M Pfeiffer

    Citation: Journal of Clinical Bioinformatics 2011 1:9

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  16. Content type: Database

    In recent years, there has been tremendous growth and interest in translational research, particularly in cancer biology. This area of study clearly establishes the connection between laboratory experimentatio...

    Authors: Mosmi Surati, Matthew Robinson, Suvobroto Nandi, Leonardo Faoro, Carley Demchuk, Cleo E Rolle, Rajani Kanteti, Benjamin D Ferguson, Rifat Hasina, Tara C Gangadhar, April K Salama, Qudsia Arif, Colin Kirchner, Eneida Mendonca, Nicholas Campbell, Suwicha Limvorasak…

    Citation: Journal of Clinical Bioinformatics 2011 1:8

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  17. Content type: Short report

    A perspective overview is given describing the current development of multiplex mass spectrometry assay technology platforms utilized for high throughput clinical sample analysis. The development of targeted t...

    Authors: Melinda Rezeli, Ákos Végvári, Thomas E Fehniger, Thomas Laurell and György Marko-Varga

    Citation: Journal of Clinical Bioinformatics 2011 1:7

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  18. Content type: Research

    Pre-B-cell colony enhancing factor 1 gene (PBEF1) encodes nicotinamide phosphoribosyltransferase (NMPRTase), which catalyses the rate limiting step in the salvage pathway of NAD+ metabolism in mammalian cells. PB...

    Authors: Nagasuma Chandra, Raghu Bhagavat, Eshita Sharma, P Sreekanthreddy and Kumaravel Somasundaram

    Citation: Journal of Clinical Bioinformatics 2011 1:5

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  19. Content type: Database

    Genome annotation plays an essential role in the interpretation and use of genome sequence information. While great strides have been made in the annotation of coding regions of genes, less success has been ac...

    Authors: Richard M Gronostajski, Joseph Guaneri, Dong Hyun Lee and Steven M Gallo

    Citation: Journal of Clinical Bioinformatics 2011 1:4

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  20. Content type: Research

    Tm-shifted melting curve SNP assays are a class of homogeneous, low-cost genotyping assays. Alleles manifest themselves as signal peaks in the neighbourhood of theoretical allele-specific melting temperatures....

    Authors: Kung-Hao Liang, Jun-Jeng Fen, Hsien-Hsun Chang, Hsei-Wei Wang and Yuchi Hwang

    Citation: Journal of Clinical Bioinformatics 2011 1:3

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  21. Content type: Review

    The search and validation of novel disease biomarkers requires the complementary power of professional study planning and execution, modern profiling technologies and related bioinformatics tools for data anal...

    Authors: Christian Baumgartner, Melanie Osl, Michael Netzer and Daniela Baumgartner

    Citation: Journal of Clinical Bioinformatics 2011 1:2

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