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Journal of Clinical Bioinformatics

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  1. Content type: Methodology

    In early-stage of cancer, primary treatment can be considered as effective at eliminating the tumor for a non-negligible proportion of patients whereas for the others it leads to a lower tumor burden and there...

    Authors: Philippe Broët and Thierry Moreau

    Citation: Journal of Clinical Bioinformatics 2012 2:14

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  2. Content type: Methodology

    A simple and fast computational model to describe the dynamics of tumour growth and metastasis formation is presented. The model is based on the calculation of successive generations of tumour cells and enable...

    Authors: Volker Haustein and Udo Schumacher

    Citation: Journal of Clinical Bioinformatics 2012 2:11

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  3. Content type: Research

    Hazelnut is reported as a causative agent of allergic reactions. However it is also an edible nut with health benefits. The allergenic characteristics of hazelnut-samples after autoclaving (AC) and high-pressu...

    Authors: Elena López, Carmen Cuadrado, Carmen Burbano, Maria Aranzazu Jiménez, Julia Rodríguez and Jesús F Crespo

    Citation: Journal of Clinical Bioinformatics 2012 2:12

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  4. Content type: Methodology

    The identification of very small subsets of predictive variables is an important toπc that has not often been considered in the literature. In order to discover highly predictive yet compact gene set classifie...

    Authors: Xiaowei Guan, Mark R Chance and Jill S Barnholtz-Sloan

    Citation: Journal of Clinical Bioinformatics 2012 2:13

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  5. Content type: Methodology

    Numerous biomedical software applications access databases maintained by the US National Center for Biotechnology Information (NCBI). To ease software automation, NCBI provides a powerful but complex Web-servi...

    Authors: Prakash M Nadkarni and Chirag R Parikh

    Citation: Journal of Clinical Bioinformatics 2012 2:9

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  6. Content type: Research

    3D domain swapping is a novel structural phenomenon observed in diverse set of protein structures in oligomeric conformations. A distinct structural feature, where structural segments in a protein dimer or hig...

    Authors: Khader Shameer and Ramanathan Sowdhamini

    Citation: Journal of Clinical Bioinformatics 2012 2:8

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  7. Content type: Review

    The 6th Benelux Bioinformatics Conference (BBC11) held in Luxembourg on 12 and 13 December 2011 attracted around 200 participants, including internationally-renowned guest speakers and more than 100 peer-reviewed...

    Authors: Francisco J Azuaje, Michaël Heymann, Anne-Marie Ternes, Anke Wienecke-Baldacchino, Daniel Struck, Danièle Moes and Reinhard Schneider

    Citation: Journal of Clinical Bioinformatics 2012 2:7

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  8. Content type: Research

    Peripheral arterial disease (PAD) is a relatively common manifestation of systemic atherosclerosis that leads to progressive narrowing of the lumen of leg arteries. Circulating monocytes are in contact with th...

    Authors: Rizwan Masud, Khader Shameer, Aparna Dhar, Keyue Ding and Iftikhar J Kullo

    Citation: Journal of Clinical Bioinformatics 2012 2:6

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  9. Content type: Research

    High blood glucose and diabetes are amongst the conditions causing the greatest losses in years of healthy life worldwide. Therefore, numerous studies aim to identify reliable risk markers for development of i...

    Authors: Manuela Hische, Abdelhalim Larhlimi, Franziska Schwarz, Antje Fischer-Rosinský, Thomas Bobbert, Anke Assmann, Gareth S Catchpole, Andreas FH Pfeiffer, Lothar Willmitzer, Joachim Selbig and Joachim Spranger

    Citation: Journal of Clinical Bioinformatics 2012 2:3

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  10. Content type: Research

    The salivary microbiota is a potential diagnostic indicator of several diseases. Culture-independent techniques are required to study the salivary microbial community since many of its members have not been cu...

    Authors: Vladimir Lazarevic, Katrine Whiteson, Nadia Gaïa, Yann Gizard, David Hernandez, Laurent Farinelli, Magne Østerås, Patrice François and Jacques Schrenzel

    Citation: Journal of Clinical Bioinformatics 2012 2:4

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  11. Content type: Short report

    Translational and evidence based medicine can take advantage of biotechnology advances that offer a fast growing variety of high-throughput data for screening molecular activities of genomic, transcriptional, ...

    Authors: Raffaele Fronza, Michele Tramonti, William R Atchley and Christine Nardini

    Citation: Journal of Clinical Bioinformatics 2012 2:2

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  12. Content type: Research

    Systematic approach for drug discovery is an emerging discipline in systems biology research area. It aims at integrating interaction data and experimental data to elucidate diseases and also raises new issues...

    Authors: Shih-Heng Yeh, Hsiang-Yuan Yeh and Von-Wun Soo

    Citation: Journal of Clinical Bioinformatics 2012 2:1

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  13. Content type: Methodology

    Multivariate assays (MVAs) for assisting clinical decisions are becoming commonly available, but due to complexity, are often considered a high-risk approach. A key concern is that uncertainty on the assay's f...

    Authors: Mark TW Ebbert, Roy RL Bastien, Kenneth M Boucher, Miguel Martín, Eva Carrasco, Rosalía Caballero, Inge J Stijleman, Philip S Bernard and Julio C Facelli

    Citation: Journal of Clinical Bioinformatics 2011 1:37

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  14. Content type: Research

    It has been shown previously that glucocorticoids exert a dual mechanism of action, entailing cytotoxic, mitogenic as well as cell proliferative and anti-apoptotic responses, in a dose-dependent manner on CCRF...

    Authors: Emmanouil G Sifakis, George I Lambrou, Andriana Prentza, Spiros Vlahopoulos, Dimitris Koutsouris, Fotini Tzortzatou-Stathopoulou and Aristotelis A Chatziioannou

    Citation: Journal of Clinical Bioinformatics 2011 1:36

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  15. Content type: Short report

    In metabolomics, biomarker discovery is a highly data driven process and requires sophisticated computational methods for the search and prioritization of novel and unforeseen biomarkers in data, typically gat...

    Authors: Michael Netzer, Klaus M Weinberger, Michael Handler, Michael Seger, Xiaocong Fang, Karl G Kugler, Armin Graber and Christian Baumgartner

    Citation: Journal of Clinical Bioinformatics 2011 1:34

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  16. Content type: Research

    Health information exchange and health information integration has become one of the top priorities for healthcare systems across institutions and hospitals. Most organizations and establishments implement hea...

    Authors: Teeradache Viangteeravat, Matthew N Anyanwu, Venkateswara Ra Nagisetty, Emin Kuscu, Mark Eijiro Sakauye and Duojiao Wu

    Citation: Journal of Clinical Bioinformatics 2011 1:32

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  17. Content type: Research

    Pulmonary Langerhans-cell histiocytosis (PLCH) is a rare interstitial lung disease characterized by clusters of Langerhans cells, organized in granulomas, in the walls of distal bronchioles. It is a diffuse lu...

    Authors: Claudia Landi, Elena Bargagli, Barbara Magi, Antje Prasse, Joachim Muller-Quernheim, Luca Bini and Paola Rottoli

    Citation: Journal of Clinical Bioinformatics 2011 1:31

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  18. Content type: Review

    Atherosclerosis results from dyslipidemia and systemic inflammation, associated with the strong metabolism and interaction between diet and disease. Strategies based on the global profiling of metabolism would...

    Authors: Duo-jiao Wu, Bi-jun Zhu and Xiang-dong Wang

    Citation: Journal of Clinical Bioinformatics 2011 1:30

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  19. Content type: Methodology

    Dyslipidemia is an important risk factor for cardiovascular disease and type II diabetes. Lipoprotein diagnostics, such as LDL cholesterol and HDL cholesterol, help to diagnose these diseases. Lipoprotein prof...

    Authors: Daniël B van Schalkwijk, Ben van Ommen, Andreas P Freidig, Jan van der Greef and Albert A de Graaf

    Citation: Journal of Clinical Bioinformatics 2011 1:29

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  20. Content type: Methodology

    The immune response to viral infection is a temporal process, represented by a dynamic and complex network of gene and protein interactions. Here, we present a reverse engineering strategy aimed at capturing t...

    Authors: Konstantina Dimitrakopoulou, Charalampos Tsimpouris, George Papadopoulos, Claudia Pommerenke, Esther Wilk, Kyriakos N Sgarbas, Klaus Schughart and Anastasios Bezerianos

    Citation: Journal of Clinical Bioinformatics 2011 1:27

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