Skip to content


Volume 5 Supplement 1

Abstracts from the 1st Clinical Research Informatics (CRI) Solutions Day 2014

  • Meeting abstract
  • Open Access

p-BioSPRE - p-medicine Biospecimen Search and Project Request Engine

Journal of Clinical Bioinformatics20155 (Suppl 1) :S20

  • Published:


  • Integration System
  • Relational Database
  • Data Integration
  • Personalized Medicine
  • Operative Version


Web-based tool, networking of biobanks for personalized medicine, metabiobank, provision of trans-institutional and trans-national access to biobanks.


p-BioSPRE is a metabiobank providing trans-institutional and transnational access to biobanks (Figure 1) while safeguarding patients’ privacy and full biobank autonomy [1].
Figure 1
Figure 1

p-BioSPRE user interface displaying as example patients’ age selection

The p-BioSPRE architecture is based on modular CRIP tools and concepts (a metadata-driven, scalable, and robust system of relational databases with an xml-based query interface) [2]. It mirrors the hub-and-spokes structure proposed by BBMRI for national and international biobank networks. Contrary to biobank registries and catalogs, p-BioSPRE allows for up-to-date queries on a case-by-case and specimen-by-specimen basis. It caters to both: researchers looking for well-annotated human specimens from all disease areas and biobank operators conveniently offering donated specimens and data for research.

p-BioSPRE is in line with the BBMRI requirements for data integration systems and the p-medicine security framework. Its central infrastructure is maintained by Fraunhofer.

Status of development

Access to the operative version of p-BioSPRE is restricted to p-medicine partners. The test and demo version 0.6 is on-line (links below) since May 23, 2014. Evaluation of p-BioSPRE by p-medicine clinical partners is ongoing until 2015.


Researchers looking for stratified human specimens.

Biobank operators looking for projects and partners to make use of donated specimens and data.




Supported by p-medicine (European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement No 270089).

Authors’ Affiliations

Fraunhofer IZI-BB, 14476 Potsdam, Germany


  1. Schröder C, Heidtke KR, Zacherl N, Zatloukal K, Taupitz J: Safeguarding donors' personal rights and biobank autonomy in biobank networks: the CRIP privacy regime. Cell Tissue Bank. 2011, 12 (1): 233-240.View ArticlePubMedGoogle Scholar
  2. Weiler G, et al: p-BioSPRE – an information and communication technology framework for transnational biomaterial sharing and access. ecancer. 2014, 8: 401-419.Google Scholar