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p-BioSPRE - p-medicine Biospecimen Search and Project Request Engine
Journal of Clinical Bioinformatics volume 5, Article number: S20 (2015)
Characterisation
Web-based tool, networking of biobanks for personalized medicine, metabiobank, provision of trans-institutional and trans-national access to biobanks.
Description
p-BioSPRE is a metabiobank providing trans-institutional and transnational access to biobanks (Figure 1) while safeguarding patients’ privacy and full biobank autonomy [1].
p-BioSPRE user interface displaying as example patients’ age selection
The p-BioSPRE architecture is based on modular CRIP tools and concepts (a metadata-driven, scalable, and robust system of relational databases with an xml-based query interface) [2]. It mirrors the hub-and-spokes structure proposed by BBMRI for national and international biobank networks. Contrary to biobank registries and catalogs, p-BioSPRE allows for up-to-date queries on a case-by-case and specimen-by-specimen basis. It caters to both: researchers looking for well-annotated human specimens from all disease areas and biobank operators conveniently offering donated specimens and data for research.
p-BioSPRE is in line with the BBMRI requirements for data integration systems and the p-medicine security framework. Its central infrastructure is maintained by Fraunhofer.
Status of development
Access to the operative version of p-BioSPRE is restricted to p-medicine partners. The test and demo version 0.6 is on-line (links below) since May 23, 2014. Evaluation of p-BioSPRE by p-medicine clinical partners is ongoing until 2015.
Users
Researchers looking for stratified human specimens.
Biobank operators looking for projects and partners to make use of donated specimens and data.
Links
p-BioSPRE Demonstrator [https://preview-crip.fraunhofer.de/intern/demo/searchtool/search/p-biospre.cgi]; CRIP Toolbox [http://www.crip.fraunhofer.de/en/toolbox]
References
Schröder C, Heidtke KR, Zacherl N, Zatloukal K, Taupitz J: Safeguarding donors' personal rights and biobank autonomy in biobank networks: the CRIP privacy regime. Cell Tissue Bank. 2011, 12 (1): 233-240.
Weiler G, et al: p-BioSPRE – an information and communication technology framework for transnational biomaterial sharing and access. ecancer. 2014, 8: 401-419.
Acknowledgement
Supported by p-medicine (European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement No 270089).
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Schröder, C., Jüttner, T. & Dobkowicz, M. p-BioSPRE - p-medicine Biospecimen Search and Project Request Engine. J Clin Bioinform 5 (Suppl 1), S20 (2015). https://doi.org/10.1186/2043-9113-5-S1-S20
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DOI: https://doi.org/10.1186/2043-9113-5-S1-S20
Keywords
- Integration System
- Relational Database
- Data Integration
- Personalized Medicine
- Operative Version